A Curated Gene and Biological System Annotation of Adverse Outcome Pathways Related to Human Health

dc.contributor.affiliationFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Institute of Biotechnology, HiLife, University of Helsinki, Helsinki, Finland-Greco, Dario
dc.contributor.authorGreco, Dario
dc.date.accessioned2025-04-29T14:07:34Z
dc.date.issued2022-11-01
dc.date.issued2022-11-01
dc.descriptionAdverse Outcome Pathways (AOPs) are multi-scale models of biological mechanisms connecting molecular initiating events to adverse outcomes through measurable key events. AOPs can guide the use and development of new approach methodologies (NAMs) aimed at reducing animal experimentation in chemical safety assessment. Here, we present a comprehensive molecular annotation of AOPs relevant to human health to embed the AOP framework into molecular data interpretation, which supports the development and application of novel AOP-based approaches in biomedical research. Please cite the following publication alongside this Zenodo entry when using the data: Saarimäki, L.A., Fratello, M., Pavel, A. et al. A curated gene and biological system annotation of adverse outcome pathways related to human health. Sci Data 10, 409 (2023). https://doi.org/10.1038/s41597-023-02321-w
dc.identifierhttps://doi.org/10.5281/zenodo.7980953
dc.identifier.urihttps://datakatalogi.helsinki.fi/handle/123456789/6852
dc.rights.licensecc-by-4.0
dc.subjectAdverse Outcome Pathways
dc.subjectToxicology
dc.subjectAnnotation
dc.titleA Curated Gene and Biological System Annotation of Adverse Outcome Pathways Related to Human Health
dc.typedataset
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