A Curated Gene and Biological System Annotation of Adverse Outcome Pathways Related to Human Health
Loading...
Restricted Availability
Date
Persistent identifier of the Data Catalogue metadata
Creator/contributor
Editor
Journal title
Journal volume
Publisher
Publication Type
dataset
Peer Review Status
Repositories
Access rights
Cite this resource
Saarimäki, L. A., Fratello, M., Pavel, A., Korpilähde, S., Leppänen, J., Serra, A., & Greco, D. (2022). A Curated Gene and Biological System Annotation of Adverse Outcome Pathways Related to Human Health (Version 2.0) [Dataset]. Zenodo. https://doi.org/10.5281/ZENODO.7980953
ISBN
ISSN
Description
Adverse Outcome Pathways (AOPs) are multi-scale models of biological mechanisms connecting molecular initiating events to adverse outcomes through measurable key events. AOPs can guide the use and development of new approach methodologies (NAMs) aimed at reducing animal experimentation in chemical safety assessment. Here, we present a comprehensive molecular annotation of AOPs relevant to human health to embed the AOP framework into molecular data interpretation, which supports the development and application of novel AOP-based approaches in biomedical research.
Please cite the following publication alongside this Zenodo entry when using the data:
Saarimäki, L.A., Fratello, M., Pavel, A. et al. A curated gene and biological system annotation of adverse outcome pathways related to human health. Sci Data 10, 409 (2023). https://doi.org/10.1038/s41597-023-02321-w
Link to original dataset
Keyword (yso)
Keywords
Adverse Outcome Pathways, Toxicology, Annotation