Data from: Tipping elements in the human intestinal ecosystem

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dc.contributor.affiliationUniversity of Helsinki-de Vos, Willem M.
dc.contributor.authorde Vos, Willem M.
dc.coverage.spatialNorthern Europe
dc.coverage.spatialNordic countries
dc.coverage.spatialEastern Europe
dc.coverage.spatialUnited States
dc.coverage.spatialEurope
dc.coverage.spatialIreland
dc.coverage.spatialSouthern Europe
dc.coverage.spatialUnited Kingdom
dc.coverage.spatialCentral Europe
dc.date.accessioned2025-04-29T13:59:23Z
dc.date.issued2015-05-19
dc.date.issued2015-05-19
dc.descriptionThe microbial communities living in the human intestine can have profound impact on our well-being and health. However, we have limited understanding of the mechanisms that control this complex ecosystem. Here, based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults, we identify groups of bacteria that exhibit robust bistable abundance distributions. These bacteria are either abundant or nearly absent in most individuals, and exhibit decreased temporal stability at the intermediate abundance range. The abundances of these bimodally distributed bacteria vary independently, and their abundance distributions are not affected by short-term dietary interventions. However, their contrasting alternative states are associated with host factors such as ageing and overweight. We propose that the bistable groups reflect tipping elements of the intestinal microbiota, whose critical transitions may have profound health implications and diagnostic potential.
dc.identifierhttps://doi.org/10.5061/dryad.pk75d
dc.identifier.urihttps://datakatalogi.helsinki.fi/handle/123456789/4216
dc.rights.licensecc-zero
dc.subjectClostridium
dc.subjectLactobacillus plantarum
dc.subjectUncultured Clostridiales
dc.subjectBacteroides fragilis
dc.subjectgut
dc.subjectClostridium difficile
dc.subjectPrevotella
dc.subjectAlternative stable states
dc.subjectbi-stability
dc.subjectUncultured Mollicutes
dc.subjecttipping element
dc.subjectcritical transitions
dc.subjectPrevotella oralis
dc.subjectPrevotella melaninogenica
dc.subjectClostridium colinum
dc.subjectDialister spp.
dc.subjecthuman
dc.titleData from: Tipping elements in the human intestinal ecosystem
dc.typedataset

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